We then investigated whether we could identify gene expression profiles in the initial core biopsy that would permit to a) predict a clinically meaningful response to Epi/Doc in terms of tumor size reduction of >30%, b) predict a profound reduction in intratumoral Ki67 protein expression, and c) predict an in vitro response to Epi/Doc in the ATP-TCA. The gene discussed is MKI67; the disease is neoplasm.