Asthma is the principle disease target, however numerous other diseases have been postulated in the literature as possible targets for 5-LOX inhibition, such as allergic rhinitis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, atherosclerosis, ischemia-reperfusion injury, atopic dermatitis and acne vulgaris [1]–[6]. Here, ALOX5 is linked to acne.