ENPP1 and diabetes mellitus: These included Slc27a, Enpp3 (and additionally Enpp1 as it has been implicated in diabetes and is adjacent to its paralog Enpp3 in the genome), Plcxd1, Neurod1 and several genes downstream of Neurod1. The expression profile of these downregulated genes was investigated in adult Mll2M2628K/+ heterozygous mutants in the metabolically important tissues liver, white adipose tissue, isolated islets and skeletal muscle (Figure 6A–D).