Lack of sufficient activity in children and adolescents, and prevalence of early obesity increase likelihood of obesity-related diseases particularly CAD in adulthood, and since the ABCA1 has an important role in RCT and subsequently the prevention of CAD, in the current study, researcher and colleagues intended to explore the effects of eight-week interval aerobic rope training program on lymphocyte ABCA1 protein expression, plasma apolipoprotein A-I and lipid profiles in overweight and obese boy adolescents. This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.