The GNAQ and GNA11 mutations associated with uveal melanoma and blue nevi occur almost exclusively in exon 5 (most commonly Q209L; Figure 1) and involve the glutamine residue within the ras-like domain, which plays an essential role in the GTP hydrolysis activity of this gene’s protein products (Van Raamsdonk et al., 2008, 2010). This evidence concerns the gene GNA11 and uveal melanoma.