Recently, germ-line mutations in BAP1, the gene encoding a tumor suppressing deubiquitinating enzyme, have been associated with predisposition to a variety of cancers including uveal and cutaneous melanoma as well as mesothelioma (Abdel-Rahman et al., 2011; Testa et al., 2011; Harbour, 2012; Wadt et al., 2012), but no studies have examined the association of germ-line mutations in GNAQ and GNA11 with uveal melanoma and blue nevi. Here, BAP1 is linked to cutaneous melanoma.