The IGF2 gene is part of a cluster together with H19, a non-coding RNA gene, and the expression of both genes is regulated by a central DMR (H19DMR).To date, the IGF2/H19 cluster and its regulation is the best-investigated imprinted region, and its role has been studied in many embryonal and adult cancers [4], [5], [9]. The gene discussed is IGF2; the disease is cancer.