KLK3 and posterior cortical atrophy: When predicting Gleason Score ≥7 PCa vs. Gleason Score<7 plus non-PCa, the sensitivity was 86% and specificity was 73% with tPSA cutoff value of 19.0 ng/mL in men ≤60 years old; the sensitivity was 75% and specificity was 72% with tPSA cutoff value of 21.0 ng/mL in men 61 to 80 years olf; the sensitivity was 72% and specificity was 70% with PSA value of 23.0 ng/mL in men ≥81 years old (Figure 2).