KLK3 and posterior cortical atrophy: When predicting Gleason Score ≥8 PCa vs. Gleason Score <8 plus non-PCa, the sensitivity was 88% and specificity was 69% with tPSA cutoff value of 19.0 ng/mL in men ≤60 years old; the sensitivity was 78% and specificity was 62% with tPSA cutoff value of 21.0 ng/mL in men 61 to 80 years old; the sensitivity was 80% and specificity was 59% with PSA value of 23.0 ng/mL in men ≥81 years old (Figure 3).