In contract, immunoreactivity for VCAM-1 was present in lipid-laden macrophage regions within fatty streaks predisposed to atherosclerosis, as was previously observed in aortic atherosclerotic plaques of STZ-induced type 1 diabetic ApoE−/−mice [16] and high-fat diet-induced type 2 diabetic LDLR−/− mice [6]. The gene discussed is VCAM1; the disease is atherosclerosis.