Considering that cells undergoing necrosis can also activate the NLRP3 inflammasome in macrophages [10], it is possible that several danger signals of inflammasomes, such as SREBP-1-mediated lipotoxic signaling, undissolved cholesterol crystals, and ATP released from necrotic cells, are involved in NLRP3-mediated induction of IL-1β in atherosclerosis. Here, SREBF1 is linked to atherosclerosis.