AMPK activation by polyphenols attenuates hepatic steatosis and ameliorates aortic atherosclerosis in insulin-resistant LDLR−/− mice, at least in part, by suppressing the cleavage processing of SREBP-1 and SREBP-2 and lipid biosynthesis in the liver [6]. The gene discussed is SREBF1; the disease is aortic atherosclerosis.