We also studied angiosarcoma, based on the observation that normal endothelial cells frequently stained positively for NICD1 and prior studies suggesting that notch1 has a tumor suppressive function in murine vascular endothelium [19,20]; hence, we were curious to see if NOTCH1 activation might be lost in human angiosarcomas. The gene discussed is NOTCH1; the disease is neoplasm.