In addition, no NICD1 staining was seen in sections of the MCL cell line MAVER-1 (Figure 1G), which has wild type NOTCH1 alleles and is devoid of NICD1 [7], or in the breast cancer cell line HCC1587 (Figure 1H), which has wild type NOTCH1 alleles and instead has an activating deletion involving NOTCH2 [10]. Here, NOTCH1 is linked to breast carcinoma.