Tumor suppressor proteins, neoplasms DNA, proto-oncogene proteins, tumor suppressor protein p53, messenger RNA, neoplasm proteins, epidermal growth factor receptor, protein-serine-threonine kinases, DNA repair enzymes, MGMT protein, DNA modification methylases, DNA-binding proteins, and biological tumor markers, are all highly associated with brain neoplasms, reflecting that they play important roles in brain tumors. This evidence concerns the gene MGMT and brain neoplasm.