To explore the possible difference on the prevalence of FTO and SH2B1 rare non-synonymous mutations in different ethnicities, we compared our results with Meyre's [23] data of French and English children with obesity and coding variants data from Exome Variant Server, NHLBI GO Exome Sequencing Project (ESP), Seattle, WA (URL: http: //evs.gs.washington.edu/EVS/). The gene discussed is FTO; the disease is Obesity.