SOD1 and amyotrophic lateral sclerosis: Although many important proteins, such as superoxide dismutase 1 (SOD1), TDP43, FUS/TLS, C9ORF72, profilin 1 and optineurin, have been identified [5], the pathogenesis of ALS is not fully understood, and the development of preventive and/or therapeutic measures for this disease is still an unmet goal.