Multiple candidate genes have been investigated to determine the relationship between single nucleotide polymorphisms (SNPs) and TB risk, including the natural resistance–associated macrophage protein 1 (NRAMP1) gene [7], interleukin (IL) genes [8], [9], vitamin D receptor (VDR) genes [10], and tumor necrosis factor (TNF) genes [11]. The gene discussed is VDR; the disease is tuberculosis.