The multiple analyses identified several covariates that were not associated with the dependent variable in the univariate analysis (e.g., TIMP1 and KCNIP3 for response to the acute SA test; KCNIP3 for the % reduction in IGF-1 and tumor reduction), and the impact of mRNA expression on these responses should be interpreted with caution. This evidence concerns the gene KCNIP3 and neoplasm.