While other studies have demonstrated that HLA-DP SNPs rs3077 and rs9277535 are strongly associated with chronic hepatitis B infection [13], [14], [15], [16], [17], [18], [19], [20], [21], to our knowledge, the present study is the first study to determine the association between rs9277378 and chronicity of HBV infection. Here, HLA-DPA1 is linked to chronic hepatitis B virus infection.