APOE and atherosclerosis: This is consistent with several adult animal exposure studies that have shown increases in atherosclerosis burden at higher doses of SHS exposure, such as apoE−/− mice to 30 mg/m3 TSP on a chow diet [19], transgenic apoB100 adult mice fed Paigen’s atherogenic diet (15% fat, 1.25% cholesterol, 0.5% sodium cholate) exposed to 25 mg/m3 TSP [35], and female apoE−/− mice fed a Western Diet (21% fat, 0.15% cholesterol) exposed to 25 mg/m3 TSP [17].