SELENOP and Glucose intolerance: In the present study, we investigated 1) the importance of SeP modulation in palmitate-induced IR in HepG2 cells; 2) the effects of salsalate and salicylate on SeP expression along with its regulatory mechanisms including AMPK and FOXO1α; 3) the influence of full-length adiponectin (fAd) on SeP expression and IR in HepG2 cells under hyperlipidemic conditions; and 4) the effects of salsalate and salicylate on hepatic SeP mRNA and protein expression along with glucose intolerance and IR in animal models.