Since we have shown in comprehensive in vitro studies that cancer stem cells can indeed be eliminated by the addition of an inhibitor of the mTOR pathways [9], we next investigated the effect of a treatment regimen comprising Gem, SIBI, and established mTOR inhibitor rapamycin (Rapa) on our representative panel of primary pancreatic cancer tissue xenografts. Here, MTOR is linked to familial pancreatic carcinoma.