[1]. Moreover, IL-6 upregulates mcl-1 expression through a STAT3-dependent pathway in cholangiocarcinoma cells [16]. However, the role of Mcl-1L in the IL-6-related pathway during liver regeneration is not well clarified. We investigated the role of the Mcl-1L anti-apoptotic protein during liver regeneration after PH in rats, including the pathway by which Mcl-1L accumulation is regulated by IL-6. This evidence concerns the gene IL6 and cholangiocarcinoma.