TNBC represents a subset of breast cancer with well documented poor prognosis, whose real causes are still to be defined even if a number of adverse factors have been advocated, such as the fact that these tumors are at the diagnosis commonly of high nuclear mitotic grade, of larger tumor size and with a more aggressive expression profile (low BCL2 and high p53 and Ki67 expression) [5], [30], [31]. The gene discussed is TP53; the disease is breast cancer.