Low expression of 4 proteins – XPF, FANCD2, MLH1 and pMK2– assessed in FFPE tumor specimens by semiquantitative immunohistochemistry, was associated with shorter recurrence free survival in multivariate analysis [47], corroborating the idea that tumors with reduced DNA repair capacity will have a higher degree of genomic instability and therefore behave more aggressively. This evidence concerns the gene ERCC4 and neoplasm.