On multivariate analysis including FGF23, MELD-Na score and GFR, refractory ascites history and the presence of hepatocarcinoma, only FGF23 plasma concentration remained significantly associated with an increased risk of death (hazard ratio 2.21; 95% CI, 1.69 to 2.92, p<0.001) (Table 4). The gene discussed is FGF23; the disease is Ascites.