In sum, Legumain-targeting liposomal nanoparticles (NPs) encapsulating HC were employed to suppress STAT3 activity and “re-educate” TAMs, and the results indicated that through inhibition of STAT3, HC-NPs was able to reverse TAMs phenotype and could regulate their crosstalk between tumor cells and TAMs. The gene discussed is LGMN; the disease is neoplasm.