TNF and tuberculosis: In addition to the increased production of Th1 cytokines (IFN-γ and TNF-α), IL-10 production was significantly higher in cured patients than Active-TB and Healthy Donors in unstimulated cultures (p = 0.002 and p = 0.001, respectively), and in antigen-stimulated cultures (p = 0.009 and p = 0.003, respectively) (Fig. 2E).