In order to analyze whether the pattern of cytokine levels observed after PBMC culture was also observed regarding its systemic levels, we quantified plasma levels of TNF-α, IFN-γ, IL-10, IL-4, IL-13, IL-6, IL-17, TGF-β and IL-22 and compared Healthy Donors, Active-TB and TB-Treated. This evidence concerns the gene IL4 and tuberculosis.