The transforming growth factor β (TGFB) family of growth factors are key regulators of mammalian development and their dysregulation is implicated in human disease, notably, heritable vasculopathies including Marfan (MFS, OMIM #154700) and Loeys–Dietz syndrome (LDS, OMIM #609192). Here, TGFB1 is linked to Marfan syndrome.