IFNB1 and viral infectious disease: Virus infection results in induction of antiviral interferons (IFNs), including type I: IFN-α and IFN-β and type III: IFN-λ1 and IFN-λ2/3, from airway cells [4] and defective rhinovirus induced IFN production has been identified in bronchial epithelial cells (BECs) [5]–[7], bronchoalveolar lavage (BAL) cells [5], [8] and peripheral blood mononuclear cells (PBMCs) [9] from asthmatic subjects.