Localisation of CDR2L to the plasma membrane suggests a possible biological function similar to other membrane associated antibodies such as AChR and P/Q voltage-gated calcium channel antibodies (VGCC) that have been shown to be of pathogenic importance in myasthenia gravis and Lambert-Eaton myasthenic syndrome [14]. The gene discussed is CDR2L; the disease is Lambert-Eaton myasthenic syndrome.