SMAD4 and neoplasm: miR-34a was also reported to target Notch signaling pathway to inhibit tumor stem cell invasion by directly binding to NOTCH1, DLL1 and JAG1 [54], [55] as well as Wnt signaling pathway by targeting WNT1 and WNT3 genes [53], [56] and TGF-β signaling pathway via Smad4[57].