Our model, which comprises all independent significant variables–age, platelet count, INR, AST, and GGT, which have been linked to liver fibrosis [10]–and Ang2, was accurate in discriminating F>1, F>2, and F>3 (AUC >0.910, all) in the training set of CHC patients (n = 107). This evidence concerns the gene ANGPT2 and cryohydrocytosis.