In conclusion, angiopoietins correlate significantly with liver fibrosis, and our new fibrosis model–comprising Ang2, age, platelet count, INR, AST, and GGT–predicts significant, moderate and severe fibrosis-cirrhosis in CHC patients with outstanding accuracy and superior diagnostic performance compared with other noninvasive liver fibrosis indices. The gene discussed is ANGPT2; the disease is cryohydrocytosis.