The progression to cirrhosis correlates with enhanced vascular density and the expression of angiogenic factors, such as VEGF-A, Ang1, and Ang2, in cirrhotic rats [52], [53], and studies have suggested that liver pathologies, such as focal nodular hyperplasia, cirrhosis, adenomas, and HCC, have a common etiology, for which Ang-1 and Ang-2 are the most informative markers for diagnosis. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.