RBFOX1 and attention deficit-hyperactivity disorder: Since then, constitutional genetic defects in RBFOX1 are implicated in multiple medical conditions including mental retardation and epilepsy [7], bipolar schizoaffective disorder [8], attention-deficit hyperactivity disorder (ADHD) [9], autism [10-13], hand osteoarthritis [14], congenital heart defects [15], obesity and diabetes [16,17], Intracranial arachnoid cysts [18], and primary biliary cirrhosis [19].