Other cancer-type specific disrupted pathways include the Sonic Hedgehog/Patched1 (SHH) Receptor Ptc1 Regulates cell cycle (PTC) pathway disrupted in renal and glioma cancers, and Role of Ran in mitotic spindle regulation (RANMS) pathway disrupted in colorectal cancer (Additional file 3: Table S13). The gene discussed is RAN; the disease is cancer.