In the subjects with three night shifts, SNPs in BMAL1 (rs2278749), BMAL2 (rs2306074), CSNK1E (rs5757037), NPAS2 (rs17024926), PER3 (rs1012477) and MTNR1A (rs131113549) were associated with decreased breast cancer risk. The gene discussed is BMAL1; the disease is breast cancer.