The data presented here demonstrate that the strong impact of CMV-infection on T cell phenotypes generally attributed to chronological ageing of the immune system is not observed exclusively in αβ T-cells, but analogously to the greater effect on αβ CD8-vs-CD4 T-cells, is also observed inVδ2- T-cells, in line with the involvement of these cells in anti-CMV immunity. The gene discussed is CD4; the disease is cytomegalovirus infection.