This viewpoint is supported by the data presented here; also, in fact, the defect in dyskerin function can modulate the IRES-mediated translation of different subgroups of cellular mRNAs while simultaneously driving both a reduction in the expression of factors limiting cell proliferation, such as tumor suppressors, and an increase in those promoting cancer cell growth, such as growth factors. The gene discussed is DKC1; the disease is neoplasm.