To demonstrate that the translation initiation of cellular IRESs can have a similar heterogeneous behavior after DKC1 KD, we analyzed the translation of IRES elements present in mRNA encoding proteins that can play important roles supporting the growth of breast cancer cells, such as those present in the oncogene c-myc and the heat shock protein 70 (HSP70) mRNAs. This evidence concerns the gene MYC and breast carcinoma.