Three different GWAS, published virtually simultaneously, provided the first convincing evidence for an association between heritable genetic variation at the nicotinic acetylcholine receptor CHRNA5/CHRNA3/CHRNB4 locus on chromosome 15q25.1 and lung cancer (Amos et al. 2008; Hung et al. 2008; Thorgeirsson et al. 2008). This evidence concerns the gene CHRNA3 and lung cancer.