The most plausible interpretation of these findings is that the P2RX7 1405G allele is a risk factor for seropositive pSS in a specific subgroup of patients who do not carry HLA risk alleles, but confers no additional risk in individuals who do, and that differences in results between the cohorts may reflect differences in adjustment for the HLA associated risk, which is only partially reflected by DR3 status. The gene discussed is TNFRSF25; the disease is peeling skin syndrome.