In these studies minimal increase in insulin secretion assessed by HOMA B in the range of 80–130 to 170–180 [13,16] or by OGTT- derived indices of beta cell function [27] fail to compensate for increased insulin resistance assessed by HOMA-IR index between 1–1.8 to 2,3 contributed to the development of gestational diabetes. This evidence concerns the gene INS and gestational diabetes.