Coefficients for ER+ and ER- subsets of breast cancers for gene SL39A6 are in stark contrast to each other, with median estimated hazard ratios of 1.61 and 1.39 for disease mortality/recurrence for ER positive patients and corresponding hazard ratios of 0.77 and 0.87 for ER negative patients. Here, ESR1 is linked to breast cancer.