INS and metabolic syndrome: In contrast, the CAPITAIN study in 14 healthy male adults with well-defined MetS showed that 6-month treatment with the highest clinically available dose of pitavastatin (4 mg/day) did not significantly change mean glucose-related or insulin-related parameters, including fasting plasma glucose, the Homeostasis Model Assessment index, insulin levels, insulin/glucose ratios, or hemoglobin A1c levels, and showed that glycemic parameters were generally improved [63].