The main findings of the study can be summarized as follows: (i) low levels of adiponectin were observed in patients with PAD; (ii) high levels of fetuin-A were observed in patients with PAD; (iii) neither SNP+45 nor SNP+276 proved to be associated with PAD; (iv) PAD proved to be significantly related to glycemia, fibrinogen, fetuin-A, TNF-α, smoking, coronary artery disease and antihypertensive therapy in a logistic regression model with an accuracy of 75.7%. This evidence concerns the gene ADIPOQ and peripheral arterial disease.