The forward LR method was applied to exclude the effects of confounders (such as gender, age, smoking status, DM, obesity, AHT, CAD, antihypertensive therapy, and biochemical parameters like cholesterol, HDL, TG, glycemia, fibrinogen, adiponectin, fetuin-A, TNF-α, duration of diabetes, oral hypoglycemic therapy, insulin therapy, oral and insulin therapy, and antihypertensive and statins therapy) as determinants other than adiponectin SNP+45 and SNP+276. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.