Tumor suppressor genes including PTEN [36], DNA mismatch repair gene hMLH1 [37], adenomatous polyposis coli (APC) [38], RAS-associated domain family member protein 1 (RASSF1A) [39], and E-cadherin [40] are more frequently silenced in type I tumor than in type II tumor. Here, CDH1 is linked to neoplasm.