However, in a similar study evaluating the ALDHBr cells derived from the osteosarcoma cell line MG63, ALDHBr as well as ALDHLow cells equally showed the ability to reconstitute the original whole cell population putting into question the validity of ALDH activity as a specific sarcoma CSC marker (Honoki et al., 2010). This evidence concerns the gene LDHA and sarcoma.