NOS2 and systemic inflammatory response syndrome: Since the systemic inflammatory response (SIRS), complement activation, release of inflammatory cytokines, expression of inducible NO synthase (iNOS), endothelial activation, and inappropriate vasodilatation play a critical role in the genesis as well as in the evolution of the cardiogenic shock, new interpretations and therapeutic strategies have been evolved to deal with this ominous consequence of the AMI, as exposed by Reynolds and Hochman (2008) [9].