In support of this, data from the Endogenous Hormones and Breast Cancer Collaborative Group (EHBCCG) [203], a pooled analysis of nine prospective studies and the European Prospective Investigation into Cancer and Nutrition (EPIC) study [204], demonstrate that postmenopausal breast cancer risk is increased among women with higher concentrations of circulating sex steroids and lower levels of SHBG. The gene discussed is SHBG; the disease is breast carcinoma.