Cancers associated with Sirtuins are, among others, SIRT1 with acute myeloid leukemia, colon, bladder, prostate, ovarian and glioma cancers; SIRT2 with glioma; SIRT3 and SIRT4 with breast cancer; SIRT 5 with pancreatic and breast cancers; SIRT6 with colon and breast cancers, and SIRT7 with breast cancer [252]. Here, SIRT4 is linked to breast cancer.