F8 and hemophilia A: FVIII is synthesized in the liver, which has been supported by the fact thatliver transplantation can cure hemophilia A. When isolating and purifying livercell populations, it has been ascertained that secretion of significant amountsof FVIII (0.07 IU/million cells/day) is observed in primary cultures of liversinusoidal endothelial cells [15].