However, after infection, AWBE-immunized animals produced antibodies to IMT/489, a synthetic peptide corresponding to position 89–105 of the schistosome cathepsin B sequence (CB2) or Sm31 antigen; this sequence position is the less antigenic region of the cathepsin B molecule since it is not exposed according to its Hopp & Wood hydrophilicity profile [57]. Here, CTSB is linked to infection.