IFNA1 and viral infectious disease: Like mammalian homologues, crucian carp IFIT-like genes possess similar expression patterns, with a silent expression in mock-induced fish cell lines but significant upregulation by either viral infection or crucian carp IFN treatment [19], [31], [34], [35].Considering the fact that the action of IFNs relies on the IFN-inducible proteins, it is worthwhile to explore the genomic structure of IFIT family genes and their expression link to IFNs.