The overall variant A allele carriers (GA+AA) also had significantly higher risk of CRC compared with the GG homozygous carriers (Adjusted OR = 1.70, 95% CI = 1.29–2.23, P<0.001), thus the variant A allele of GRP78 rs430397 polymorphism may be a deleterious allele as well. This evidence concerns the gene HSPA5 and colorectal carcinoma.