Compared with the CC homozygous genotype of GRP78 rs391957 polymorphism, the CT heterozygous (Adjusted OR = 1.39, 95% CI = 1.06–1.83, P = 0.018) and TT homozygous (Adjusted OR = 2.10, 95% CI = 1.06–4.14, P = 0.033) genotypes were both significantly associated with higher risk of CRC. Here, HSPA5 is linked to colorectal carcinoma.