HSPA5 and colorectal carcinoma: The overall variant T allele carriers (CT+TT) also had significantly higher risk of CRC compared with the CC homozygous carriers (Adjusted OR = 1.45, 95% CI = 1.11–1.89, P = 0.006), suggesting that the variant T allele of GRP78 rs391957 polymorphism may be a deleterious allele.