Du and colleagues have demonstrated that CRT as an upstream regulator of STAT3 promotes cell motility and enhances resistance to anoikis in esophageal squamous cell carcinoma [13], while another study has shown that CRT is an upstream signaling molecule of STAT3, and inhibits STAT3 signaling and function [12]. The gene discussed is CALR; the disease is esophageal squamous cell carcinoma.