FOXP3 and inflammatory bowel disease: It was originally described in murine cells as a heterodimeric suppressive cytokine secreted from Foxp3+ Tregs [the Ebi gene is a downstream target of Foxp3 (Collison et al., 2007)], without which the suppressive function of Tregs was significantly reduced, rendering Tregs incapable of controlling experimental inflammatory bowel disease (Collison et al., 2007).