FOXP3 and polyendocrinopathy: The Foxp3 gene is highly conserved between species and a mutation in the human gene, FOXP3, was identified as the causative factor responsible for the human equivalent of Scurfy, the Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity and allergic dysregulation syndrome (XLAAD) (Chatila et al., 2000; Bennett et al., 2001; Hori et al., 2003).