On the other hand, TGFβ—dependent profibrotic signaling in response to myocardial infarction is blunted in Cx43+/− mice compared to Cx43+/+ mice, leading to a decrease in post-infarct fibrosis (Zhang et al., 2010b), probably because of the difference in Cx43 expression in fibroblasts (Zhang et al., 2010a). The gene discussed is GJA1; the disease is myocardial infarction.